{"id":236,"date":"2015-05-01T05:12:44","date_gmt":"2015-05-01T05:12:44","guid":{"rendered":"http:\/\/www.griffithasiainsights.com.au\/?p=236"},"modified":"2016-04-13T18:52:40","modified_gmt":"2016-04-13T08:52:40","slug":"funding-boost-for-eskitis-malaria-research","status":"publish","type":"post","link":"https:\/\/testblogs.griffith.edu.au\/asiainsights\/funding-boost-for-eskitis-malaria-research\/","title":{"rendered":"Funding boost for Eskitis malaria research"},"content":{"rendered":"

Griffith University\u2019s contribution to the international fight against malaria has received a major boost from Japan\u2019s Global Health Innovative Technology Fund (GHIT<\/a>).<\/p>\n

Following an investment of $US637,000, a research team from Griffith\u2019s Eskitis Institute for Drug Discovery<\/a> and led by Professor Vicky Avery\u2013 along with partners from Japanese pharmaceutical firm Daiichi Sankyo, the Swiss-based Medicines for Malaria Venture (MMV<\/a>), Monash University and the University of California-San Diego \u2014 can make advances towards more effective anti-malarial drugs through their collective efforts.<\/p>\n

Professor Avery says the ultimate aim is to develop a medicine that treats malaria caused by Plasmodium falciparum and Plasmodium vivax, combats drug resistance and, ideally, prevents relapse associated with parasite dormancy.<\/p>\n

As well as treating patients, the researchers are focusing on ways to protect people from being infected and, critically, of blocking transmission of the parasite to the mosquito host. Attacking the parasite at multiple stages of the life cycle is necessary to achieve the goal of malaria eradication.<\/p>\n

High quality drug discovery<\/strong><\/p>\n

\u201cThis new project extends our ongoing long-term collaboration with MMV and the more recent one with GHIT, which has been responsible for identifying new chemical entities for progression through the drug discovery pipeline,\u201d says Professor Avery.<\/p>\n

\u201cOur involvement has been as a result of the high quality drug discovery efforts in malaria undertaken in my laboratory.<\/p>\n

\u201cThe assays developed to undertake the screening and biological profiling of compounds in search of new leads are based on state of the art image-based technologies.<\/p>\n

\u201cWe have proven that within an academic environment we can undertake drug discovery at industry standards. Indeed, we are equipped with systems which usually would only be found within large Pharma.\u201d<\/p>\n

Launched in 2013 with an initial commitment of more than $US100 million, the GHIT Fund is a public-private partnership between six Japanese pharmaceutical companies, the Japanese Government and the Bill & Melinda Gates Foundation.<\/p>\n

The latest announcement marks GHIT\u2019s second round of funding to support very early-stage drug research through its \u201cHit-to-Lead Platform\u201d.<\/p>\n

This initiative invests in projects with the goal of converting drug \u201chits\u201d from compound libraries into \u201clead compounds\u201d that show promise against infectious diseases but require further research and development before testing as human drugs.<\/p>\n

Inhibiting parasite growth<\/strong><\/p>\n

In the first phase, GHIT invested in Professor Avery\u2019s team to undertake the screening of 50,000 compounds from Daiichi Sankyo, which identified several \u201chit\u201d series able to inhibit the malaria parasite growth.<\/p>\n

According to the World Health Organisation, the global malaria death rate decreased by 47 per cent from 2000-13. However, challenges such as inevitable resistance to malaria drugs continue to pose a serious threat.<\/p>\n

\u201cThe drug discovery efforts within the Eskitis Institute are well recognised globally, which is highlighted by our extensive collaborations and high quality publications,\u201d says Professor Avery.<\/p>\n

\u201cDrug discovery is a multidisciplinary process, hence being able to collaborate well with individuals from different disciplines is essential.\u00a0I believe this is something we do well.<\/p>\n

\u201cI also believe that with the concerted and focused efforts that everyone is now taking in their drug discovery efforts, and the requirement that new drugs have activity against different stages of the parasite life cycle, including blocking transmission, we have a very good chance of providing a suite of new drugs to alleviate the current concerns with resistance.\u201d<\/p>\n

For more information, please visit the Impact @ Griffith Sciences<\/a> website.<\/p>\n","protected":false},"excerpt":{"rendered":"

Griffith University\u2019s contribution to the international fight against malaria has received a major boost from Japan\u2019s Global Health Innovative Technology Fund (GHIT). Following an investment of $US637,000, a research team from Griffith\u2019s Eskitis Institute for Drug Discovery and led by Professor Vicky Avery\u2013 along with partners from Japanese pharmaceutical firm Daiichi Sankyo, the Swiss-based MedicinesContinue reading “Funding boost for Eskitis malaria research”<\/span><\/a><\/p>\n","protected":false},"author":14,"featured_media":1905,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_newsletter_tier_id":0,"footnotes":""},"categories":[245],"tags":[322,497,353,403,449],"class_list":["post-236","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-china-and-north-east-asia","tag-eskitis-institute-for-drug-discovery","tag-international-health","tag-japan","tag-professor-vicky-avery","tag-world-health-organization"],"acf":[],"modified_by":"Christine Kowalski","yoast_head":"\nFunding boost for Eskitis malaria research | Griffith Asia Insights<\/title>\n<meta name=\"description\" content=\"Griffith University\u2019s contribution to the international fight against malaria has received a major boost from Japan\u2019s Global 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